Kenneth ChengMathematical modeling

Editorial project overview

Drug Dissolution Model Hierarchy

When do empirical drug-release laws stop being adequate descriptions of finite-volume dissolution?

Reproducible studyUpdated 2 Aug 2026
Technical figure from Drug Dissolution Model Hierarchy
A reviewed research figure synchronized from the private technical workspace. The original aspect ratio and labels are preserved.

Editorial overview

Read When Do Simple Drug-Release Laws Stop Being Enough? for the model hierarchy, transport atlas, local exponent, model discrimination, identifiability, polydispersity, conservation audit, and nine approved figures.

The public page interprets reviewed outputs without exposing private notebooks, solver source, raw observations, or calculation notes.

Key findings

  • The finite-sink PDE has the lowest AIC, -179.924, among the declared candidates.
  • The final released fraction is 0.9750 and maximum numerical mass-balance error is 3.11e-13.

Limitations

  • Results use synthetic observations and do not support clinical or formulation claims.
  • Swelling, degradation, non-Fickian transport, and experimental batch variability are outside scope.

Technical record

Detailed source, calculations, generated figures, and reproduction instructions are maintained in a private technical workspace. Public articles contain only manually reviewed interpretation and approved figures.

Version history

2026-08-02 — Curated overview reviewed against repository evidence.